One clinical trial each: the question, the design, the numbers with an original chart, how far they can be trusted, and what changed in practice. Written for cardiology fellows.
- DanGer Shock (2024) faculty-reviewed
DanGer Shock — microaxial flow pump plus standard care vs standard care alone in STEMI with cardiogenic shock
- SHOCK (1999) draft — not yet faculty-reviewed
SHOCK — emergency revascularization vs initial medical stabilization in acute MI with cardiogenic shock
- CULPRIT-SHOCK (2017) faculty-reviewed
CULPRIT-SHOCK — culprit-lesion-only PCI vs immediate multivessel PCI in acute MI with cardiogenic shock and multivessel disease
- IABP-SHOCK II (2012) draft — not yet faculty-reviewed
IABP-SHOCK II — intra-aortic balloon pump vs no balloon pump in acute myocardial infarction with cardiogenic shock
- ISAR-SHOCK (2008) draft — not yet faculty-reviewed
ISAR-SHOCK — Impella LP2.5 microaxial pump vs intra-aortic balloon pump in cardiogenic shock after acute myocardial infarction
- IMPRESS (2017) draft — not yet faculty-reviewed
IMPRESS — Impella CP microaxial pump vs intra-aortic balloon pump in severe cardiogenic shock after acute myocardial infarction
- ECLS-SHOCK (2023) draft — not yet faculty-reviewed
ECLS-SHOCK — early VA-ECMO plus usual care vs usual care alone in AMI with cardiogenic shock and planned revascularization
- ECMO-CS (2023) draft — not yet faculty-reviewed
ECMO-CS — immediate VA-ECMO vs early conservative therapy in rapidly deteriorating or severe cardiogenic shock
- HYPO-ECMO (2022) draft — not yet faculty-reviewed
HYPO-ECMO — moderate hypothermia vs normothermia in cardiogenic shock treated with VA-ECMO
- STEMI-DTU (2026) draft — not yet faculty-reviewed
STEMI-DTU — microaxial pump unloading for 30 minutes before PCI vs immediate PCI in anterior STEMI WITHOUT cardiogenic shock
- SOAP II (2010) draft — not yet faculty-reviewed
SOAP II — dopamine vs norepinephrine as first-line vasopressor in shock of all causes (cardiogenic-shock subgroup)
- OptimaCC (2018) draft — not yet faculty-reviewed
OptimaCC — epinephrine vs norepinephrine in cardiogenic shock after acute MI
- DOREMI (2021) draft — not yet faculty-reviewed
DOREMI — milrinone vs dobutamine in cardiogenic shock
- COMMIT (2005) draft — not yet faculty-reviewed
COMMIT (metoprolol) — early IV then oral metoprolol vs placebo in acute MI, and the cardiogenic shock it caused
- ESCAPE (2005) draft — not yet faculty-reviewed
ESCAPE — pulmonary artery catheter-guided therapy vs clinical assessment alone in severe heart failure without shock
- COACT (2019) draft — not yet faculty-reviewed
COACT — immediate vs delayed coronary angiography in resuscitated cardiac arrest without STEMI (cardiac-arrest box; not a STEMI shock trial)
- TOMAHAWK (2021) draft — not yet faculty-reviewed
TOMAHAWK — immediate vs delayed or selective coronary angiography in resuscitated cardiac arrest without ST elevation (cardiac-arrest box; not a STEMI shock trial)